PARP INHIBITOR OLAPARIB OVERCOMES SORAFENIB RESISTANCE THROUGH RESHAPING THE PLURIPOTENT TRANSCRIPTOME IN HEPATOCELLULAR CARCINOMA

PARP inhibitor Olaparib overcomes Sorafenib resistance through reshaping the pluripotent transcriptome in hepatocellular carcinoma

Abstract Hepatocellular carcinoma (HCC) is one of the most common human malignancies worldwide with very poor prognosis.Resistance to targeted therapeutic drugs such as sorafenib remains one of the major challenges in clinical treatment.In the present study, PARP1 was found to be highly expressed in human embryonic stem cells, but progressively dec

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Experimental analysis of process parameters in drilling nimonic C263 alloy under nano fluid mixed MQL environment

Nimonic C263 is a super alloy and it is difficult to cut.As this alloy possess high proportion of chromium, cobalt, and molybdenum, which fortify the material by solution hardening, which inhibits the dislocation movement, resulting in higher plastic deformation.In this research, an attempt has been Scopes made to model, analysis and investigate th

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